Cooper - A 2 Year old male Mastiff “Cooper” is a 2 year-old male neutered mastiff X with severe osteoarthritis secondary to hip dysplasia in both hips “Cooper” was reluctant to climb stairs or play with other dogs in the family and sat and stood with difficulty. He was only mildly responsive to NSAIDS. “Cooper” was treated with adult-derived mesenchymalstem cells, which were injected into both hip joints. “Cooper” showed great improvement within a month. Owners comment “A dramatic improvement in climbing stairs and now playing with other dogs.” Lameness - Walking Pre-Treat 30 Days Non-detectable   x Intermittent     Persistant x   Lameness - Trotting     Non-detectable     Intermittent   x Persistant x   Pain on Manipulation     No pain   x Mild pain x   Severe pain     Range of Motion     No limitation     Pain only at full flexion/extension   x Pain at less than full flexion/extension x   Pain at any attempt     Functional Disability     Normal activity     Slightly stiff gait   x Stiff gait     Very stiff gait x   Does not want to walk